Miller Group


Welcome to the Miller research group, based at Keele University

We are a group of organic chemists focused on carbohydrate synthesis. We are interested in making tools for glycobiology, new glyco-based biomaterials and carbohydrates in medicinal chemistry. Please browse the site using the links above and follow us on Twitter @millerlabkeele


Logo (1)



We are recruiting!

3-yr PDRA position in Carbohydrate Synthesis

A postdoctoral position is available within the group to carry out research on a project funded by EPSRC. The focus is in carbohydrate synthesis and will involve synthesis of a series of oligosaccharide targets. For full details of the job advert, specification and how to apply, see here. Please email GJM (attach a CV) for informal inquiries.



Fully funded 4 yr PhD studentship in Chemoenzymatic Carbohydrate Synthesis

We are seeking a motivated candidate for a Keele funded PhD research project entitled: 'Precursor-directed biosynthesis of non-natural oligosaccharides: enabling tools to explore polysaccharide structure-property relationships.' This is a collaborative project with Rob Field's lab at the Manchester Institute of Biotechnology and Unilever. For informal inquiries please email GJM (attach a CV) or see the full advert and application process here.




Group News

Jan 2021 - Sean Evans has joined as a PhD student working on synthesis for polysaccharide structure-function tools with Unilever, welcome Sean!


Nov 2020 - Laura and Eleni's paper uncovering the first sugar nucleotide inhibitor of the GDP-mannose dehydrogenase from Pseudomonas aeruginosa is now published in ACS Chem. Biol., see here.


Oct 2020 - Dr Imlirenla Pongener has joined us from the McGarrigle group at UCD as the first UKRI FLF PDRA, to work on heparan sulphate synthesis. Hannah Wootton and Conor O'Shea have also joined as PhD students working on glycosaminoglycan synthesis, welcome all!


Oct 2020 - Dr Meenakshi Singh joins us from Prof Lugi Lay's group in Milan as an EPSRC-SFI funded PDRA to work on fluorescent labelling and oligosaccharide synthesis. Welcome Meenakshi!

Apr 2020
- Mieke and Caecilie's article covering recent advances in the chemical synthesis of nucleoside analogues for anticancer research has been published in Molecules.

Mar 2020 - A second collaborative preprint with Mark Skidmore, Scott Guimond and Marcelo Lima at Keele on heparin preventing SARS-CoV-2 invasion is out now on bioRxiv.

Apr 2020
- GJM has been awarded a UKRI Future Leaders Fellowship. See press release here.

Mar 2020 - A collaborative preprint with Mark Skidmore, Scott Guimond and Marcelo Lima at Keele on heparin binding to the CoV2 surface is out now on bioRxiv.

Mar 2020 - Laura has alsopassed her PhD viva with minor corrections. Huge congratulations and thanks to Prof. Sabine Flitsch (MIB) and Dr Matthew O'Brien (Keele) for examining.
Feb 2020 - Eleni has passed her PhD viva with minor corrections. Huge congratulations and thanks to Prof. Stefan Oscarson (UCD) and Dr Mike Edwards (Keele) for examining.
Viva celebrations
9a89220f-a4d2-43e1-a0ab-92fd1608b533af40b222-4b82-440f-a4b1-2dc010d99095IMG_5240

Jan 2019 - A collaborative paper with Dr Mark Skidmore and colleagues at Keele using chondroitin sulfate extracts to inhibit BACE1 is out now in Neural Regeneration Research.

Dec 2019 - Laura, Eleni and Hannah's paper exploring anomeric glycosylation of phosphoric acid is out now in Carbohydrate Research.

Dec 2019 - Eleni and Laura have both submitted their PhD theses! Congratulations!

17929169-5888-47c4-a930-091b50205742

Oct 2019 - Lloyd Murphy and Alex Compton have started as MChem researchers working on nucleoside analogue projects, welcome both!

Oct 2019
- Alice Wahart has joined the group as a PhD student working on polysaccharide building blocks in collaboration with Croda, welcome Alice!

Oct 2019
- Eleni's paper on the synthesis of hydroxamate-modified alginate disaccharides is out now in a special web-themed issue on Glycosylation in Organic and Biomolecular Chemistry.

Sept 2019
- Jack Porter has joined the group as a PhD student working on polysaccharide building blocks in collaboration with Croda, welcome Jack!

Sept 2019
- Laura's paper on the synthesis of the sugar nucleotide GDP-ManA is out now in Carbohydrate Research.

June 2019
- Our paper using a chemoenzymatic approach towards sugar-nucleotide structure-function tools for a bacterial dehydrogenase is out now in Organic Letters.

June 2019 - Keele end of year ball 2019

ball


March 2019
- Celebrating International Women's Day 2019 (with a hostage!)

5e673e05-c5d5-47fd-a0ab-195eda9a55dc

Sept 20198- Eleni's paper using flow synthesis to access pharmaceutically relevant heterocyles is out now in Tetrahedron. A collaborative project with Dr Matthew O'Brien at Keele.